Guests of the Cafe have access to the full range of Inspiration Corporation's programs, including employment training and career services, voice mail, and subsidized housing. Inspiration Cafe's goal is to help men and women overcome the causes of their homelessness and find stability by securing income and affordable housing.

Inspiration Cafe was founded in 1989 by Lisa Nigro, a Chicago police officer who began searching for a personal response to the homelessness she encountered in Uptown. She began by loading up a red wagon with sandwiches and coffee to distribute to homeless individuals on the streets.